Urine abnormalities after Doxycycline in dogs

The FDA has received 41 reports of urine abnormalities in dogs after Doxycycline. That is 1.0% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

41Reports

76%Marked serious

4.9%Recovered

34%Died or euthanised

15 daysTypical onset

How soon it started

Same day

5 17%

1–2 days

3 10%

3–7 days

6 20%

1–4 weeks

6 20%

Over a month

10 33%

How the animals did

Recovered

2 4.9%

Still unwell when reported

19 46%

Died

3 7.3%

Euthanised

11 27%

Not known

6 15%

Problems reported at the same time

32 78%

22 54%

22 54%

20 49%

18 44%

18 44%

17 41%

15 37%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Doxycycline treats bacterial and tick-borne infections.

Questions owners ask

Can Doxycycline cause urine abnormalities in dogs?: 41 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 15 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Urine abnormalities with similar medicines

Urine abnormalities after Amoxicillin + Clavulanate (Clavamox) 75 reports · 1.4% of its reports
Urine abnormalities after Cefovecin (Convenia) 30 reports · 0.8% of its reports
Urine abnormalities after Enrofloxacin (Baytril) 52 reports · 1.4% of its reports
Urine abnormalities after Metronidazole 43 reports · 1.4% of its reports
Urine abnormalities after Amoxicillin 36 reports · 2.7% of its reports

All reported side effects of Doxycycline in dogs · Medicines most reported with urine abnormalities