Urine abnormalities after Amoxicillin + Clavulanate (Clavamox) in dogs

The FDA has received 75 reports of urine abnormalities in dogs after Amoxicillin + Clavulanate. That is 1.4% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

75Reports
65%Marked serious
5.3%Recovered
25%Died or euthanised
14 daysTypical onset
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How soon it started

Same day
4 6.8%
1–2 days
8 14%
3–7 days
10 17%
1–4 weeks
14 24%
Over a month
23 39%

How the animals did

Recovered
3 4.0%
Recovered with lasting effects
1 1.3%
Still unwell when reported
40 53%
Died
7 9.3%
Euthanised
12 16%
Not known
12 16%

Problems reported at the same time

Age of the animals

Under 1 year
9
1–3 years
5
4–7 years
21
8–11 years
23
12+ years
17

About this medicine

Amoxicillin treats bacterial infections.

Products with this combination include Clavamox. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Amoxicillin + Clavulanate cause urine abnormalities in dogs?
75 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 14 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Urine abnormalities with similar medicines

All reported side effects of Amoxicillin + Clavulanate in dogs · Medicines most reported with urine abnormalities