Elevated cholesterol (total) after Doxycycline in dogs

35 reports to the FDA describe elevated cholesterol (total) in dogs given Doxycycline. That is 0.9% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

35Reports
80%Marked serious
5.7%Recovered
40%Died or euthanised
26 daysTypical onset
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How soon it started

Same day
4 15%
1–2 days
1 3.8%
3–7 days
3 12%
1–4 weeks
6 23%
Over a month
12 46%

How the animals did

Recovered
2 5.7%
Still unwell when reported
12 34%
Euthanised
14 40%
Not known
7 20%

Problems reported at the same time

Age of the animals

Under 1 year
4
1–3 years
1
4–7 years
16
8–11 years
5
12+ years
9

About this medicine

Doxycycline treats bacterial and tick-borne infections.

Questions owners ask

Can Doxycycline cause elevated cholesterol (total) in dogs?
35 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 26 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Elevated cholesterol (total) with similar medicines

All reported side effects of Doxycycline in dogs · Medicines most reported with elevated cholesterol (total)