Wound after Diphenhydramine in dogs

75 reports to the FDA describe wound in dogs given Diphenhydramine. That is 1.6% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

75Reports

39%Marked serious

13%Recovered

8.0%Died or euthanised

5 daysTypical onset

How soon it started

Same day

12 20%

1–2 days

7 12%

3–7 days

14 23%

1–4 weeks

18 30%

Over a month

9 15%

How the animals did

Recovered

10 13%

Still unwell when reported

15 20%

Died

1 1.3%

Euthanised

5 6.7%

Not known

44 59%

Problems reported at the same time

Injection site reaction

59 79%

53 71%

32 43%

31 41%

30 40%

22 29%

21 28%

Didn't work as expected

19 25%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Diphenhydramine cause wound in dogs?: 75 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 5 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Wound with similar medicines

Wound after Butorphanol 102 reports · 2.3% of its reports
Wound after Propofol 35 reports · 1.1% of its reports
Wound after Isoflurane 24 reports · 0.9% of its reports
Wound after Atipamezole 62 reports · 2.3% of its reports
Wound after Famotidine 63 reports · 2.4% of its reports
Wound after Tigilanol Tiglate 416 reports · 21% of its reports

All reported side effects of Diphenhydramine in dogs · Medicines most reported with wound