Pain after Diphenhydramine in dogs

173 reports to the FDA describe pain in dogs given Diphenhydramine. That is 3.7% of all reports for this medicine, compared with 0.7% across reports for all dog medicines, so it is reported unusually often with this medicine.

173Reports
47%Marked serious
18%Recovered
12%Died or euthanised
2 daysTypical onset
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How soon it started

Same day
51 35%
1–2 days
22 15%
3–7 days
22 15%
1–4 weeks
20 14%
Over a month
29 20%

How the animals did

Recovered
32 18%
Still unwell when reported
64 37%
Died
10 5.8%
Euthanised
10 5.8%
Not known
57 33%

Problems reported at the same time

Age of the animals

Under 1 year
10
1–3 years
30
4–7 years
63
8–11 years
56
12+ years
13

About this medicine

Type: medicine.

Questions owners ask

Can Diphenhydramine cause pain in dogs?
173 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 2 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Pain with similar medicines

All reported side effects of Diphenhydramine in dogs · Medicines most reported with pain