Regurgitation after Diphenhydramine in dogs

The FDA has received 39 reports of regurgitation in dogs after Diphenhydramine. That is 0.8% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

39Reports
77%Marked serious
21%Recovered
15%Died or euthanised
2 daysTypical onset
SponsoredWorried about your pet? Ask a veterinarian online, 24/7

How soon it started

Same day
15 44%
1–2 days
4 12%
3–7 days
2 5.9%
1–4 weeks
2 5.9%
Over a month
11 32%

How the animals did

Recovered
8 21%
Still unwell when reported
18 46%
Euthanised
6 15%
Not known
7 18%

Problems reported at the same time

Age of the animals

Under 1 year
3
1–3 years
7
4–7 years
20
8–11 years
6
12+ years
3

About this medicine

Type: medicine.

Questions owners ask

Can Diphenhydramine cause regurgitation in dogs?
39 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 2 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Regurgitation with similar medicines

All reported side effects of Diphenhydramine in dogs · Medicines most reported with regurgitation