Not himself/herself after Diphenhydramine in dogs

60 reports to the FDA describe not himself/herself in dogs given Diphenhydramine. That is 1.3% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

60Reports

78%Marked serious

22%Recovered

18%Died or euthanised

1 daysTypical onset

How soon it started

Same day

23 40%

1–2 days

12 21%

3–7 days

3 5.3%

1–4 weeks

12 21%

Over a month

7 12%

How the animals did

Recovered

13 22%

Still unwell when reported

23 38%

Died

3 5.0%

Euthanised

8 13%

Not known

13 22%

Problems reported at the same time

31 52%

30 50%

24 40%

21 35%

20 33%

19 32%

Injection site reaction

11 18%

Death

10 17%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Diphenhydramine cause not himself/herself in dogs?: 60 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Not himself/herself with similar medicines

Not himself/herself after Melarsomine (Immiticide) 21 reports · 0.1% of its reports
Not himself/herself after Polysulfated Glycosaminoglycan 25 reports · 0.5% of its reports
Not himself/herself after Butorphanol 49 reports · 1.1% of its reports
Not himself/herself after Cefpodoxime 21 reports · 0.5% of its reports
Not himself/herself after Florfenicol + Mometasone + Terbinafine 29 reports · 0.8% of its reports
Not himself/herself after Desoxycorticosterone Pivalate 20 reports · 0.6% of its reports
Not himself/herself after Famotidine 33 reports · 1.2% of its reports
Not himself/herself after Chondroitin + Glucosamine 20 reports · 0.8% of its reports
Not himself/herself after Glucosamine 22 reports · 1.2% of its reports
Not himself/herself after Sucralfate 20 reports · 2.0% of its reports

All reported side effects of Diphenhydramine in dogs · Medicines most reported with not himself/herself