Mass after Diphenhydramine in dogs

The FDA has received 29 reports of mass in dogs after Diphenhydramine. That is 0.6% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

29Reports
59%Marked serious
14%Recovered
10%Died or euthanised
16 daysTypical onset
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How soon it started

Same day
1 4.0%
1–2 days
4 16%
3–7 days
5 20%
1–4 weeks
3 12%
Over a month
12 48%

How the animals did

Recovered
4 14%
Still unwell when reported
4 14%
Died
1 3.4%
Euthanised
2 6.9%
Not known
18 62%

Problems reported at the same time

Age of the animals

Under 1 year
0
1–3 years
3
4–7 years
7
8–11 years
14
12+ years
2

About this medicine

Type: medicine.

Questions owners ask

Can Diphenhydramine cause mass in dogs?
29 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 16 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Mass with similar medicines

All reported side effects of Diphenhydramine in dogs · Medicines most reported with mass