Limb non-weight bearing after Diphenhydramine in dogs

33 reports to the FDA describe limb non-weight bearing in dogs given Diphenhydramine. That is 0.7% of all reports for this medicine, compared with 0.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

33Reports

36%Marked serious

18%Recovered

3.0%Died or euthanised

3 daysTypical onset

How soon it started

Same day

3 10%

1–2 days

9 31%

3–7 days

4 14%

1–4 weeks

9 31%

Over a month

4 14%

How the animals did

Recovered

6 18%

Still unwell when reported

6 18%

Euthanised

1 3.0%

Not known

20 61%

Problems reported at the same time

Injection site reaction

27 82%

26 79%

22 67%

21 64%

20 61%

14 42%

12 36%

9 27%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Diphenhydramine cause limb non-weight bearing in dogs?: 33 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 3 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Limb non-weight bearing with similar medicines

Limb non-weight bearing after Butorphanol 59 reports · 1.3% of its reports
Limb non-weight bearing after Atipamezole 25 reports · 0.9% of its reports
Limb non-weight bearing after Famotidine 31 reports · 1.2% of its reports
Limb non-weight bearing after Tigilanol Tiglate 176 reports · 8.7% of its reports

All reported side effects of Diphenhydramine in dogs · Medicines most reported with limb non-weight bearing