Elevated temperature after Diphenhydramine in dogs

64 reports to the FDA describe elevated temperature in dogs given Diphenhydramine. That is 1.4% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

64Reports
75%Marked serious
22%Recovered
17%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
38 64%
1–2 days
4 6.8%
3–7 days
6 10%
1–4 weeks
5 8.5%
Over a month
6 10%

How the animals did

Recovered
14 22%
Still unwell when reported
27 42%
Died
5 7.8%
Euthanised
6 9.4%
Not known
12 19%

Problems reported at the same time

Age of the animals

Under 1 year
6
1–3 years
18
4–7 years
17
8–11 years
18
12+ years
5

About this medicine

Type: medicine.

Questions owners ask

Can Diphenhydramine cause elevated temperature in dogs?
64 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Elevated temperature with similar medicines

All reported side effects of Diphenhydramine in dogs · Medicines most reported with elevated temperature