Drooling after Diphenhydramine in dogs

The FDA has received 208 reports of drooling in dogs after Diphenhydramine. That is 4.4% of all reports for this medicine, compared with 1.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

208Reports
72%Marked serious
26%Recovered
21%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
103 59%
1–2 days
22 13%
3–7 days
10 5.7%
1–4 weeks
15 8.5%
Over a month
26 15%

How the animals did

Recovered
51 25%
Recovered with lasting effects
3 1.4%
Still unwell when reported
80 38%
Died
19 9.1%
Euthanised
25 12%
Not known
30 14%

Problems reported at the same time

Age of the animals

Under 1 year
34
1–3 years
65
4–7 years
52
8–11 years
35
12+ years
21

About this medicine

Type: medicine.

Questions owners ask

Can Diphenhydramine cause drooling in dogs?
208 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Drooling with similar medicines

All reported side effects of Diphenhydramine in dogs · Medicines most reported with drooling