Cardiac arrest after Diphenhydramine in dogs
The FDA has received 49 reports of cardiac arrest in dogs after Diphenhydramine. That is 1.0% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.
49Reports
100%Marked serious
0.0%Recovered
100%Died or euthanised
Same dayTypical onset
Sponsored
How soon it started
How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Type: medicine.
Questions owners ask
- Can Diphenhydramine cause cardiac arrest in dogs?
- 49 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- How soon after a dose was it reported?
- In half of the reports with dates, it started within the same day of the first dose.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Cardiac arrest with similar medicines
- Cardiac arrest after Melarsomine (Immiticide) 45 reports · 0.2% of its reports
- Cardiac arrest after Butorphanol 218 reports · 4.9% of its reports
- Cardiac arrest after Tramadol 20 reports · 0.5% of its reports
- Cardiac arrest after Propofol 280 reports · 9.1% of its reports
- Cardiac arrest after Isoflurane 233 reports · 8.4% of its reports
- Cardiac arrest after Atipamezole 145 reports · 5.5% of its reports
- Cardiac arrest after Famotidine 34 reports · 1.3% of its reports
- Cardiac arrest after Medetomidine 138 reports · 6.5% of its reports
- Cardiac arrest after Ketamine 120 reports · 6.4% of its reports
- Cardiac arrest after Acepromazine 69 reports · 3.9% of its reports
All reported side effects of Diphenhydramine in dogs · Medicines most reported with cardiac arrest