Bacterial skin infection after Diphenhydramine in dogs

36 reports to the FDA describe bacterial skin infection in dogs given Diphenhydramine. That is 0.8% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

36Reports
69%Marked serious
5.6%Recovered
8.3%Died or euthanised
9 daysTypical onset
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How soon it started

Same day
3 12%
1–2 days
6 24%
3–7 days
2 8.0%
1–4 weeks
10 40%
Over a month
4 16%

How the animals did

Recovered
2 5.6%
Still unwell when reported
16 44%
Died
1 2.8%
Euthanised
2 5.6%
Not known
15 42%

Problems reported at the same time

Age of the animals

Under 1 year
2
1–3 years
8
4–7 years
14
8–11 years
11
12+ years
0

About this medicine

Type: medicine.

Questions owners ask

Can Diphenhydramine cause bacterial skin infection in dogs?
36 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 9 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Bacterial skin infection with similar medicines

All reported side effects of Diphenhydramine in dogs · Medicines most reported with bacterial skin infection