Liver problems after Dexamethasone in dogs

500 reports to the FDA describe liver problems in dogs given Dexamethasone. That is 18% of all reports for this medicine, compared with 4.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

500Reports
83%Marked serious
9.4%Recovered
39%Died or euthanised
4 daysTypical onset
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How soon it started

Same day
138 32%
1–2 days
61 14%
3–7 days
60 14%
1–4 weeks
79 18%
Over a month
96 22%

How the animals did

Recovered
44 8.8%
Recovered with lasting effects
3 0.6%
Still unwell when reported
209 42%
Died
80 16%
Euthanised
113 23%
Not known
51 10%

Problems reported at the same time

Age of the animals

Under 1 year
33
1–3 years
115
4–7 years
141
8–11 years
142
12+ years
68

About this medicine

Dexamethasone reduces inflammation and immune activity.

Steroids commonly cause increased thirst, urination and appetite, especially at higher doses.

Questions owners ask

Can Dexamethasone cause liver problems in dogs?
500 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 4 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Liver problems with similar medicines

All reported side effects of Dexamethasone in dogs · Medicines most reported with liver problems