Liver problems after Miconazole + Polymyxin B + Prednisolone in dogs

25 reports to the FDA describe liver problems in dogs given Miconazole + Polymyxin B + Prednisolone. That is 2.3% of all reports for this medicine, compared with 4.6% across reports for all dog medicines, so it is reported less often than average with this medicine.

25Reports
64%Marked serious
20%Recovered
20%Died or euthanised
19 daysTypical onset
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How soon it started

Same day
2 13%
1–2 days
3 19%
3–7 days
1 6.3%
1–4 weeks
4 25%
Over a month
6 38%

How the animals did

Recovered
4 16%
Recovered with lasting effects
1 4.0%
Still unwell when reported
4 16%
Euthanised
5 20%
Not known
11 44%

Problems reported at the same time

Death
5 20%
Kidney problems
4 16%
Ocular discharge
4 16%
Excessive thirst
4 16%

Age of the animals

Under 1 year
2
1–3 years
9
4–7 years
3
8–11 years
9
12+ years
2

About this medicine

Prednisolone reduces inflammation and immune activity.

Steroids commonly cause increased thirst, urination and appetite, especially at higher doses.

Questions owners ask

Can Miconazole + Polymyxin B + Prednisolone cause liver problems in dogs?
25 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 19 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Liver problems with similar medicines

All reported side effects of Miconazole + Polymyxin B + Prednisolone in dogs · Medicines most reported with liver problems