Papilloma after Cyclosporine (Atopica) in dogs

The FDA has received 48 reports of papilloma in dogs after Cyclosporine. That is 0.3% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

48Reports

73%Marked serious

23%Recovered

4.2%Died or euthanised

61 daysTypical onset

How soon it started

Same day

3 9.7%

1–2 days

0 0.0%

3–7 days

2 6.5%

1–4 weeks

8 26%

Over a month

18 58%

How the animals did

Recovered

10 21%

Recovered with lasting effects

1 2.1%

Still unwell when reported

28 58%

Euthanised

2 4.2%

Not known

7 15%

Problems reported at the same time

Loss of appetite

6 13%

Skin rash or irritation

5 10%

Didn't work as expected

4 8.3%

4 8.3%

4 8.3%

4 8.3%

3 6.3%

3 6.3%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Cyclosporine controls allergic skin disease and some immune conditions.

Products with this ingredient include Atopica. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Cyclosporine cause papilloma in dogs?: 48 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 61 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Papilloma with similar medicines

Papilloma after Oclacitinib (Apoquel) 421 reports · 1.5% of its reports
Papilloma after Ilunocitinib (Zenrelia) 32 reports · 1.5% of its reports

All reported side effects of Cyclosporine in dogs · Medicines most reported with papilloma