Gingival hyperplasia after Cyclosporine (Atopica) in dogs

569 reports to the FDA describe gingival hyperplasia in dogs given Cyclosporine. That is 3.7% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

569Reports

32%Marked serious

7.4%Recovered

2.3%Died or euthanised

120 daysTypical onset

How soon it started

Same day

17 14%

1–2 days

2 1.6%

3–7 days

2 1.6%

1–4 weeks

13 11%

Over a month

89 72%

How the animals did

Recovered

35 6.2%

Recovered with lasting effects

7 1.2%

Still unwell when reported

157 28%

Died

10 1.8%

Euthanised

3 0.5%

Not known

357 63%

Problems reported at the same time

Vomiting

51 9.0%

Diarrhea

40 7.0%

Skin rash or irritation

35 6.2%

26 4.6%

23 4.0%

23 4.0%

23 4.0%

21 3.7%

Age of the animals

Under 1 year

1–3 years

4–7 years

224

8–11 years

181

12+ years

About this medicine

Cyclosporine controls allergic skin disease and some immune conditions.

Products with this ingredient include Atopica. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Cyclosporine cause gingival hyperplasia in dogs?: 569 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 120 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Gingival hyperplasia with similar medicines

Gingival hyperplasia after Oclacitinib (Apoquel) 73 reports · 0.3% of its reports

All reported side effects of Cyclosporine in dogs · Medicines most reported with gingival hyperplasia