Monocytosis after Bedinvetmab (Librela) in dogs

The FDA has received 180 reports of monocytosis in dogs after Bedinvetmab. That is 0.9% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

180Reports

91%Marked serious

2.2%Recovered

44%Died or euthanised

8 daysTypical onset

How soon it started

Same day

20 14%

1–2 days

31 21%

3–7 days

22 15%

1–4 weeks

38 26%

Over a month

36 24%

How the animals did

Recovered

4 2.2%

Still unwell when reported

91 51%

Died

23 13%

Euthanised

56 31%

Not known

6 3.3%

Problems reported at the same time

116 64%

95 53%

93 52%

80 44%

78 43%

73 41%

73 41%

64 36%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Bedinvetmab reduces osteoarthritis pain in dogs (monthly injection).

Products with this ingredient include Librela. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Bedinvetmab cause monocytosis in dogs?: 180 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 8 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Monocytosis with similar medicines

Monocytosis after Lokivetmab (Cytopoint) 93 reports · 1.4% of its reports

All reported side effects of Bedinvetmab in dogs · Medicines most reported with monocytosis