Kidney problems after Bedinvetmab (Librela) in dogs

The FDA has received 1,332 reports of kidney problems in dogs after Bedinvetmab. That is 6.8% of all reports for this medicine, compared with 2.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

1,332Reports

81%Marked serious

2.7%Recovered

35%Died or euthanised

14 daysTypical onset

How soon it started

Same day

199 18%

1–2 days

144 13%

3–7 days

126 11%

1–4 weeks

274 24%

Over a month

394 35%

How the animals did

Recovered

33 2.5%

Recovered with lasting effects

3 0.2%

Still unwell when reported

733 55%

Died

99 7.4%

Euthanised

364 27%

Not known

100 7.5%

Problems reported at the same time

546 41%

463 35%

459 34%

379 28%

360 27%

Elevated symmetrical dimethylarginine (sdma)

228 17%

Excessive thirst

226 17%

Diarrhea

225 17%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

365

12+ years

860

About this medicine

Bedinvetmab reduces osteoarthritis pain in dogs (monthly injection).

Products with this ingredient include Librela. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Bedinvetmab cause kidney problems in dogs?: 1,332 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 14 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Kidney problems with similar medicines

Kidney problems after Lokivetmab (Cytopoint) 248 reports · 3.8% of its reports

All reported side effects of Bedinvetmab in dogs · Medicines most reported with kidney problems