Inappropriate urination after Amoxicillin + Clavulanate (Clavamox) in dogs

The FDA has received 71 reports of inappropriate urination in dogs after Amoxicillin + Clavulanate. That is 1.3% of all reports for this medicine, compared with 0.5% across reports for all dog medicines, so it is reported unusually often with this medicine.

71Reports

69%Marked serious

17%Recovered

21%Died or euthanised

7 daysTypical onset

How soon it started

Same day

12 20%

1–2 days

11 18%

3–7 days

10 17%

1–4 weeks

9 15%

Over a month

18 30%

How the animals did

Recovered

11 15%

Recovered with lasting effects

1 1.4%

Still unwell when reported

30 42%

Died

10 14%

Euthanised

5 7.0%

Not known

14 20%

Problems reported at the same time

Vomiting

36 51%

Loss of appetite

32 45%

Urinary tract infection

25 35%

19 27%

18 25%

16 23%

15 21%

Didn't work as expected

15 21%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Amoxicillin treats bacterial infections.

Products with this combination include Clavamox. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Amoxicillin + Clavulanate cause inappropriate urination in dogs?: 71 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 7 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Inappropriate urination with similar medicines

Inappropriate urination after Doxycycline 48 reports · 1.2% of its reports
Inappropriate urination after Cefovecin (Convenia) 36 reports · 1.0% of its reports
Inappropriate urination after Enrofloxacin (Baytril) 54 reports · 1.4% of its reports
Inappropriate urination after Metronidazole 38 reports · 1.2% of its reports
Inappropriate urination after Amoxicillin 36 reports · 2.7% of its reports

All reported side effects of Amoxicillin + Clavulanate in dogs · Medicines most reported with inappropriate urination