Hypercalcaemia after Amoxicillin + Clavulanate (Clavamox) in dogs

30 reports to the FDA describe hypercalcaemia in dogs given Amoxicillin + Clavulanate. That is 0.6% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

30Reports

53%Marked serious

10%Recovered

40%Died or euthanised

17 daysTypical onset

How soon it started

Same day

1 6.3%

1–2 days

2 13%

3–7 days

2 13%

1–4 weeks

5 31%

Over a month

6 38%

How the animals did

Recovered

3 10%

Still unwell when reported

9 30%

Died

8 27%

Euthanised

4 13%

Not known

6 20%

Problems reported at the same time

19 63%

17 57%

16 53%

14 47%

14 47%

14 47%

12 40%

12 40%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Amoxicillin treats bacterial infections.

Products with this combination include Clavamox. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Amoxicillin + Clavulanate cause hypercalcaemia in dogs?: 30 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 17 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Hypercalcaemia with similar medicines

Hypercalcaemia after Doxycycline 22 reports · 0.5% of its reports
Hypercalcaemia after Cefovecin (Convenia) 20 reports · 0.5% of its reports

All reported side effects of Amoxicillin + Clavulanate in dogs · Medicines most reported with hypercalcaemia