Disorientation after Amoxicillin + Clavulanate (Clavamox) in dogs

The FDA has received 111 reports of disorientation in dogs after Amoxicillin + Clavulanate. That is 2.1% of all reports for this medicine, compared with 1.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

111Reports
50%Marked serious
8.1%Recovered
32%Died or euthanised
3 daysTypical onset
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How soon it started

Same day
22 30%
1–2 days
11 15%
3–7 days
12 16%
1–4 weeks
17 23%
Over a month
11 15%

How the animals did

Recovered
8 7.2%
Recovered with lasting effects
1 0.9%
Still unwell when reported
29 26%
Died
17 15%
Euthanised
19 17%
Not known
37 33%

Problems reported at the same time

Age of the animals

Under 1 year
7
1–3 years
14
4–7 years
21
8–11 years
29
12+ years
39

About this medicine

Amoxicillin treats bacterial infections.

Products with this combination include Clavamox. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Amoxicillin + Clavulanate cause disorientation in dogs?
111 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 3 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Disorientation with similar medicines

All reported side effects of Amoxicillin + Clavulanate in dogs · Medicines most reported with disorientation