Dehydration after Amoxicillin + Clavulanate (Clavamox) in dogs

The FDA has received 150 reports of dehydration in dogs after Amoxicillin + Clavulanate. That is 2.8% of all reports for this medicine, compared with 0.7% across reports for all dog medicines, so it is reported unusually often with this medicine.

150Reports
55%Marked serious
9.3%Recovered
34%Died or euthanised
7 daysTypical onset
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How soon it started

Same day
14 15%
1–2 days
18 19%
3–7 days
18 19%
1–4 weeks
20 21%
Over a month
25 26%

How the animals did

Recovered
12 8.0%
Recovered with lasting effects
2 1.3%
Still unwell when reported
44 29%
Died
27 18%
Euthanised
24 16%
Not known
41 27%

Problems reported at the same time

Age of the animals

Under 1 year
26
1–3 years
26
4–7 years
38
8–11 years
33
12+ years
25

About this medicine

Amoxicillin treats bacterial infections.

Products with this combination include Clavamox. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Amoxicillin + Clavulanate cause dehydration in dogs?
150 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 7 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Dehydration with similar medicines

All reported side effects of Amoxicillin + Clavulanate in dogs · Medicines most reported with dehydration