Lethargy after Amitriptyline in dogs

The FDA has received 26 reports of lethargy in dogs after Amitriptyline. That is 20% of all reports for this medicine, compared with 11% across reports for all dog medicines, so it is reported unusually often with this medicine.

26Reports
42%Marked serious
50%Recovered
23%Died or euthanised
60 daysTypical onset
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How soon it started

Same day
1 6.3%
1–2 days
1 6.3%
3–7 days
3 19%
1–4 weeks
2 13%
Over a month
9 56%

How the animals did

Recovered
11 42%
Recovered with lasting effects
2 7.7%
Still unwell when reported
4 15%
Died
2 7.7%
Euthanised
4 15%
Not known
3 12%

Problems reported at the same time

13 50%
Loss of appetite
8 31%
Death
6 23%
Kidney problems
6 23%
Liver problems
5 19%
Diarrhea
5 19%
Behaviour change
4 15%
Not himself/herself
4 15%

Age of the animals

Under 1 year
1
1–3 years
9
4–7 years
1
8–11 years
10
12+ years
4

About this medicine

Type: medicine.

Questions owners ask

Can Amitriptyline cause lethargy in dogs?
26 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 60 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Lethargy with similar medicines

All reported side effects of Amitriptyline in dogs · Medicines most reported with lethargy