Proteinuria after Velagliflozin (Senvelgo) in cats

The FDA has received 133 reports of proteinuria in cats after Velagliflozin. That is 2.8% of all reports for this medicine, compared with 0.5% across reports for all cat medicines, so it is reported unusually often with this medicine.

133Reports

42%Marked serious

3.0%Recovered

23%Died or euthanised

8 daysTypical onset

How soon it started

Same day

9 8.4%

1–2 days

22 21%

3–7 days

21 20%

1–4 weeks

23 21%

Over a month

32 30%

How the animals did

Recovered

4 3.0%

Still unwell when reported

14 11%

Died

8 6.0%

Euthanised

22 17%

Not known

85 64%

Problems reported at the same time

57 43%

53 40%

52 39%

51 38%

46 35%

44 33%

44 33%

39 29%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Velagliflozin treats diabetes in cats (oral, an SGLT2 inhibitor).

Products with this ingredient include Senvelgo. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Velagliflozin cause proteinuria in cats?: 133 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 8 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Proteinuria with similar medicines

Proteinuria after Bexagliflozin (Bexacat) 99 reports · 2.4% of its reports
Proteinuria after Insulin 36 reports · 1.0% of its reports

All reported side effects of Velagliflozin in cats · Medicines most reported with proteinuria