Ketonuria after Velagliflozin (Senvelgo) in cats

The FDA has received 574 reports of ketonuria in cats after Velagliflozin. That is 12% of all reports for this medicine, compared with 0.5% across reports for all cat medicines, so it is reported unusually often with this medicine.

574Reports

35%Marked serious

7.3%Recovered

18%Died or euthanised

3 daysTypical onset

How soon it started

Same day

25 4.6%

1–2 days

165 31%

3–7 days

203 38%

1–4 weeks

75 14%

Over a month

71 13%

How the animals did

Recovered

42 7.3%

Still unwell when reported

68 12%

Died

21 3.7%

Euthanised

80 14%

Not known

363 63%

Problems reported at the same time

207 36%

181 32%

136 24%

131 23%

101 18%

96 17%

93 16%

Diabetic ketoacidosis

74 13%

Age of the animals

Under 1 year

1–3 years

4–7 years

115

8–11 years

251

12+ years

175

About this medicine

Velagliflozin treats diabetes in cats (oral, an SGLT2 inhibitor).

Products with this ingredient include Senvelgo. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Velagliflozin cause ketonuria in cats?: 574 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 3 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Ketonuria with similar medicines

Ketonuria after Bexagliflozin (Bexacat) 130 reports · 3.2% of its reports
Ketonuria after Insulin 31 reports · 0.8% of its reports

All reported side effects of Velagliflozin in cats · Medicines most reported with ketonuria