Liver problems after Velagliflozin (Senvelgo) in cats

The FDA has received 339 reports of liver problems in cats after Velagliflozin. That is 7.1% of all reports for this medicine, compared with 2.8% across reports for all cat medicines, so it is reported unusually often with this medicine.

339Reports
58%Marked serious
6.2%Recovered
28%Died or euthanised
7 daysTypical onset
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How soon it started

Same day
23 7.8%
1–2 days
73 25%
3–7 days
64 22%
1–4 weeks
53 18%
Over a month
82 28%

How the animals did

Recovered
20 5.9%
Recovered with lasting effects
1 0.3%
Still unwell when reported
63 19%
Died
18 5.3%
Euthanised
78 23%
Not known
159 47%

Problems reported at the same time

Age of the animals

Under 1 year
0
1–3 years
4
4–7 years
58
8–11 years
160
12+ years
113

About this medicine

Velagliflozin treats diabetes in cats (oral, an SGLT2 inhibitor).

Products with this ingredient include Senvelgo. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Velagliflozin cause liver problems in cats?
339 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 7 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Liver problems with similar medicines

All reported side effects of Velagliflozin in cats · Medicines most reported with liver problems