Hypochloraemia after Velagliflozin (Senvelgo) in cats

The FDA has received 179 reports of hypochloraemia in cats after Velagliflozin. That is 3.7% of all reports for this medicine, compared with 0.4% across reports for all cat medicines, so it is reported unusually often with this medicine.

179Reports

59%Marked serious

6.7%Recovered

28%Died or euthanised

8 daysTypical onset

How soon it started

Same day

12 7.8%

1–2 days

32 21%

3–7 days

30 20%

1–4 weeks

35 23%

Over a month

44 29%

How the animals did

Recovered

12 6.7%

Still unwell when reported

31 17%

Died

10 5.6%

Euthanised

41 23%

Not known

85 47%

Problems reported at the same time

96 54%

91 51%

91 51%

89 50%

79 44%

78 44%

74 41%

Elevated cholesterol (total)

65 36%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Velagliflozin treats diabetes in cats (oral, an SGLT2 inhibitor).

Products with this ingredient include Senvelgo. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Velagliflozin cause hypochloraemia in cats?: 179 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 8 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Hypochloraemia with similar medicines

Hypochloraemia after Bexagliflozin (Bexacat) 82 reports · 2.0% of its reports
Hypochloraemia after Insulin 31 reports · 0.8% of its reports

All reported side effects of Velagliflozin in cats · Medicines most reported with hypochloraemia