Elevated cholesterol (total) after Velagliflozin (Senvelgo) in cats

184 reports to the FDA describe elevated cholesterol (total) in cats given Velagliflozin. That is 3.8% of all reports for this medicine, compared with 0.4% across reports for all cat medicines, so it is reported unusually often with this medicine.

184Reports
40%Marked serious
4.9%Recovered
17%Died or euthanised
22 daysTypical onset
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How soon it started

Same day
11 6.9%
1–2 days
23 14%
3–7 days
29 18%
1–4 weeks
26 16%
Over a month
70 44%

How the animals did

Recovered
9 4.9%
Still unwell when reported
31 17%
Died
7 3.8%
Euthanised
24 13%
Not known
113 61%

Problems reported at the same time

Age of the animals

Under 1 year
0
1–3 years
1
4–7 years
21
8–11 years
94
12+ years
65

About this medicine

Velagliflozin treats diabetes in cats (oral, an SGLT2 inhibitor).

Products with this ingredient include Senvelgo. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Velagliflozin cause elevated cholesterol (total) in cats?
184 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 22 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Elevated cholesterol (total) with similar medicines

All reported side effects of Velagliflozin in cats · Medicines most reported with elevated cholesterol (total)