Unresponsive after Tiletamine + Zolazepam in cats

The FDA has received 21 reports of unresponsive in cats after Tiletamine + Zolazepam. That is 1.3% of all reports for this medicine, compared with 0.6% across reports for all cat medicines, so it is reported unusually often with this medicine.

21Reports

33%Marked serious

9.5%Recovered

48%Died or euthanised

–Typical onset

How the animals did

Recovered

2 9.5%

Still unwell when reported

2 9.5%

Died

8 38%

Euthanised

2 9.5%

Not known

7 33%

Problems reported at the same time

Death

10 48%

Wobbliness (ataxia)

5 24%

Cardiac arrest

5 24%

Loss of consciousness

4 19%

4 19%

4 19%

4 19%

3 14%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Tiletamine + Zolazepam cause unresponsive in cats?: 21 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Unresponsive with similar medicines

Unresponsive after Ketamine 56 reports · 1.7% of its reports
Unresponsive after Butorphanol 45 reports · 2.0% of its reports
Unresponsive after Isoflurane 41 reports · 2.0% of its reports
Unresponsive after Methylprednisolone 23 reports · 1.4% of its reports
Unresponsive after Propofol 32 reports · 2.7% of its reports
Unresponsive after Midazolam 24 reports · 3.2% of its reports

All reported side effects of Tiletamine + Zolazepam in cats · Medicines most reported with unresponsive