Unresponsive after Midazolam in cats

The FDA has received 24 reports of unresponsive in cats after Midazolam. That is 3.2% of all reports for this medicine, compared with 0.6% across reports for all cat medicines, so it is reported unusually often with this medicine.

24Reports

100%Marked serious

21%Recovered

38%Died or euthanised

1 daysTypical onset

How soon it started

Same day

6 35%

1–2 days

6 35%

3–7 days

1 5.9%

1–4 weeks

1 5.9%

Over a month

3 18%

How the animals did

Recovered

5 21%

Still unwell when reported

3 13%

Died

2 8.3%

Euthanised

7 29%

Not known

7 29%

Problems reported at the same time

Death

9 38%

Pale mucous membrane

6 25%

6 25%

5 21%

5 21%

4 17%

Elevated globulins

4 17%

Low platelet count

4 17%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Midazolam cause unresponsive in cats?: 24 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Unresponsive with similar medicines

Unresponsive after Ketamine 56 reports · 1.7% of its reports
Unresponsive after Butorphanol 45 reports · 2.0% of its reports
Unresponsive after Isoflurane 41 reports · 2.0% of its reports
Unresponsive after Tiletamine + Zolazepam 21 reports · 1.3% of its reports
Unresponsive after Methylprednisolone 23 reports · 1.4% of its reports
Unresponsive after Propofol 32 reports · 2.7% of its reports

All reported side effects of Midazolam in cats · Medicines most reported with unresponsive