Breathing problems after Ivermectin + Praziquantel in horses

53 reports to the FDA describe breathing problems in horses given Ivermectin + Praziquantel. That is 2.0% of all reports for this medicine, compared with 3.4% across reports for all horse medicines, so it is reported less often than average with this medicine.

53Reports
25%Marked serious
28%Recovered
7.5%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
11 79%
1–2 days
0 0.0%
3–7 days
0 0.0%
1–4 weeks
0 0.0%
Over a month
3 21%

How the animals did

Recovered
15 28%
Died
4 7.5%
Not known
34 64%

Problems reported at the same time

Swelling
32 60%
Drooling
13 25%
Loss of appetite
13 25%
Tachycardia
10 19%
Allergic reaction
8 15%
Fever
7 13%
Lethargy
7 13%
Recumbency
6 11%

Age of the animals

Under 1 year
1
1–3 years
3
4–7 years
4
8–11 years
12
12+ years
24

About this medicine

Ivermectin prevents heartworm disease (monthly). Praziquantel treats tapeworms.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Ivermectin + Praziquantel cause breathing problems in horses?
53 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Breathing problems with similar medicines

All reported side effects of Ivermectin + Praziquantel in horses · Medicines most reported with breathing problems