Fever after Ivermectin + Praziquantel in horses

46 reports to the FDA describe fever in horses given Ivermectin + Praziquantel. That is 1.7% of all reports for this medicine, compared with 4.8% across reports for all horse medicines, so it is reported less often than average with this medicine.

46Reports

13%Marked serious

8.7%Recovered

20%Died or euthanised

–Typical onset

How the animals did

Recovered

4 8.7%

Still unwell when reported

2 4.3%

Died

6 13%

Euthanised

3 6.5%

Not known

31 67%

Problems reported at the same time

21 46%

18 39%

16 35%

11 24%

10 22%

8 17%

7 15%

6 13%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Ivermectin prevents heartworm disease (monthly). Praziquantel treats tapeworms.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Ivermectin + Praziquantel cause fever in horses?: 46 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Fever with similar medicines

Fever after Moxidectin (ProHeart 6) 57 reports · 4.2% of its reports
Fever after Ivermectin (Heartgard) 34 reports · 4.9% of its reports
Fever after Moxidectin + Praziquantel 29 reports · 7.8% of its reports

All reported side effects of Ivermectin + Praziquantel in horses · Medicines most reported with fever