Injection site reaction after Trazodone in dogs

The FDA has received 121 reports of injection site reaction in dogs after Trazodone. That is 4.8% of all reports for this medicine, compared with 1.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

121Reports

47%Marked serious

18%Recovered

6.6%Died or euthanised

11 daysTypical onset

How soon it started

Same day

24 22%

1–2 days

12 11%

3–7 days

14 13%

1–4 weeks

31 28%

Over a month

29 26%

How the animals did

Recovered

22 18%

Still unwell when reported

49 40%

Died

4 3.3%

Euthanised

4 3.3%

Not known

42 35%

Problems reported at the same time

Swelling

58 48%

Loss of appetite

26 21%

Lethargy

20 17%

Didn't work as expected

17 14%

17 14%

15 12%

14 12%

14 12%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Trazodone reduces anxiety and stress.

Questions owners ask

Can Trazodone cause injection site reaction in dogs?: 121 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 11 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Injection site reaction with similar medicines

Injection site reaction after Gabapentin 439 reports · 4.9% of its reports

All reported side effects of Trazodone in dogs · Medicines most reported with injection site reaction