Swelling after Trazodone in dogs

The FDA has received 206 reports of swelling in dogs after Trazodone. That is 8.1% of all reports for this medicine, compared with 2.8% across reports for all dog medicines, so it is reported unusually often with this medicine.

206Reports

65%Marked serious

18%Recovered

15%Died or euthanised

6 daysTypical onset

How soon it started

Same day

50 27%

1–2 days

18 9.9%

3–7 days

28 15%

1–4 weeks

38 21%

Over a month

48 26%

How the animals did

Recovered

38 18%

Still unwell when reported

94 46%

Died

16 7.8%

Euthanised

15 7.3%

Not known

43 21%

Problems reported at the same time

Loss of appetite

58 28%

Injection site reaction

58 28%

44 21%

44 21%

40 19%

36 17%

33 16%

31 15%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Trazodone reduces anxiety and stress.

Questions owners ask

Can Trazodone cause swelling in dogs?: 206 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 6 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Swelling with similar medicines

Swelling after Gabapentin 648 reports · 7.2% of its reports
Swelling after Selegiline (Anipryl) 36 reports · 0.9% of its reports
Swelling after Fluoxetine 42 reports · 1.6% of its reports

All reported side effects of Trazodone in dogs · Medicines most reported with swelling