Skin disorders after Selamectin (Revolution) in dogs

The FDA has received 42 reports of skin disorders in dogs after Selamectin. That is 0.1% of all reports for this medicine, compared with 0.5% across reports for all dog medicines, so it is reported less often than average with this medicine.

42Reports

14%Marked serious

9.5%Recovered

7.1%Died or euthanised

13 daysTypical onset

How soon it started

Same day

8 27%

1–2 days

4 13%

3–7 days

3 10%

1–4 weeks

6 20%

Over a month

9 30%

How the animals did

Recovered

3 7.1%

Recovered with lasting effects

1 2.4%

Still unwell when reported

18 43%

Died

1 2.4%

Euthanised

2 4.8%

Not known

17 40%

Problems reported at the same time

16 38%

11 26%

9 21%

9 21%

Didn't work as expected

9 21%

Didn't stop fleas

6 14%

Loss of appetite

6 14%

Skin rash or irritation

6 14%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Selamectin prevents heartworm and treats fleas, ear mites and some worms (spot-on).

Products with this ingredient include Revolution. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Selamectin cause skin disorders in dogs?: 42 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 13 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Skin disorders with similar medicines

Skin disorders after Ivermectin + Pyrantel (Heartgard Plus) 153 reports · 0.1% of its reports
Skin disorders after Milbemycin Oxime + Spinosad (Trifexis) 576 reports · 0.4% of its reports
Skin disorders after Moxidectin (ProHeart 6) 50 reports · 0.1% of its reports
Skin disorders after Milbemycin Oxime + Praziquantel (Interceptor Plus) 118 reports · 0.4% of its reports
Skin disorders after Milbemycin Oxime (Interceptor) 35 reports · 0.1% of its reports
Skin disorders after Ivermectin (Heartgard) 47 reports · 0.4% of its reports

All reported side effects of Selamectin in dogs · Medicines most reported with skin disorders