Drug dose administration interval too long after Selamectin (Revolution) in dogs

The FDA has received 55 reports of drug dose administration interval too long in dogs after Selamectin. That is 0.2% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported less often than average with this medicine.

55Reports
16%Marked serious
5.5%Recovered
0.0%Died or euthanised
50 daysTypical onset
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How soon it started

Same day
0 0.0%
1–2 days
2 15%
3–7 days
0 0.0%
1–4 weeks
1 7.7%
Over a month
10 77%

How the animals did

Recovered
3 5.5%
Still unwell when reported
35 64%
Not known
17 31%

Problems reported at the same time

Age of the animals

Under 1 year
7
1–3 years
18
4–7 years
14
8–11 years
11
12+ years
1

About this medicine

Selamectin prevents heartworm and treats fleas, ear mites and some worms (spot-on).

Products with this ingredient include Revolution. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Selamectin cause drug dose administration interval too long in dogs?
55 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 50 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Drug dose administration interval too long with similar medicines

All reported side effects of Selamectin in dogs · Medicines most reported with drug dose administration interval too long