Loose stool after Sarolaner (Simparica) in dogs

178 reports to the FDA describe loose stool in dogs given Sarolaner. That is 1.1% of all reports for this medicine, compared with 0.9% across reports for all dog medicines.

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How soon it started

How the animals did

Problems reported at the same time

Age of the animals

About this medicine

Sarolaner kills fleas, ticks and some mites; monthly.

Products with this ingredient include Simparica. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Sarolaner cause loose stool in dogs?

178 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.

How soon after a dose was it reported?

In half of the reports with dates, it started within 1 day of the first dose.

What should I do?

Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Loose stool with similar medicines

• Loose stool after Fluralaner (Bravecto) 614 reports · 0.9% of its reports
• Loose stool after Afoxolaner (NexGard) 703 reports · 1.2% of its reports
• Loose stool after Lotilaner (Credelio) 159 reports · 1.6% of its reports
• Loose stool after Afoxolaner + Moxidectin + Pyrantel (NexGard PLUS) 89 reports · 1.0% of its reports
• Loose stool after Lotilaner + Moxidectin + Praziquantel + Pyrantel (Credelio Quattro) 62 reports · 2.0% of its reports

All reported side effects of Sarolaner in dogs · Medicines most reported with loose stool