Loose stool after Fluralaner (Bravecto) in dogs

The FDA has received 614 reports of loose stool in dogs after Fluralaner. That is 0.9% of all reports for this medicine, compared with 0.9% across reports for all dog medicines.

614Reports

71%Marked serious

30%Recovered

7.5%Died or euthanised

1 daysTypical onset

How soon it started

Same day

142 33%

1–2 days

140 32%

3–7 days

47 11%

1–4 weeks

39 9.0%

Over a month

67 15%

How the animals did

Recovered

179 29%

Recovered with lasting effects

4 0.7%

Still unwell when reported

292 48%

Died

12 2.0%

Euthanised

34 5.5%

Not known

93 15%

Problems reported at the same time

260 42%

201 33%

199 32%

113 18%

59 9.6%

46 7.5%

43 7.0%

41 6.7%

Age of the animals

Under 1 year

1–3 years

197

4–7 years

140

8–11 years

130

12+ years

About this medicine

Fluralaner kills fleas and ticks for up to 12 weeks (chewable or spot-on).

Products with this ingredient include Bravecto. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Fluralaner cause loose stool in dogs?: 614 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Loose stool with similar medicines

Loose stool after Afoxolaner (NexGard) 703 reports · 1.2% of its reports
Loose stool after Sarolaner (Simparica) 178 reports · 1.1% of its reports
Loose stool after Lotilaner (Credelio) 159 reports · 1.6% of its reports
Loose stool after Afoxolaner + Moxidectin + Pyrantel (NexGard PLUS) 89 reports · 1.0% of its reports
Loose stool after Lotilaner + Moxidectin + Praziquantel + Pyrantel (Credelio Quattro) 62 reports · 2.0% of its reports

All reported side effects of Fluralaner in dogs · Medicines most reported with loose stool