Appetite loss after Sarolaner (Simparica) in dogs

48 reports to the FDA describe appetite loss in dogs given Sarolaner. That is 0.3% of all reports for this medicine, compared with 0.3% across reports for all dog medicines.

48Reports

38%Marked serious

33%Recovered

8.3%Died or euthanised

1 daysTypical onset

How soon it started

Same day

17 40%

1–2 days

14 33%

3–7 days

3 7.1%

1–4 weeks

5 12%

Over a month

3 7.1%

How the animals did

Recovered

16 33%

Still unwell when reported

13 27%

Died

3 6.3%

Euthanised

1 2.1%

Not known

15 31%

Problems reported at the same time

24 50%

23 48%

14 29%

8 17%

4 8.3%

4 8.3%

4 8.3%

4 8.3%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Sarolaner kills fleas, ticks and some mites; monthly.

Products with this ingredient include Simparica. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Sarolaner cause appetite loss in dogs?: 48 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Appetite loss with similar medicines

Appetite loss after Fluralaner (Bravecto) 206 reports · 0.3% of its reports
Appetite loss after Afoxolaner (NexGard) 601 reports · 1.1% of its reports
Appetite loss after Lotilaner (Credelio) 37 reports · 0.4% of its reports
Appetite loss after Afoxolaner + Moxidectin + Pyrantel (NexGard PLUS) 37 reports · 0.4% of its reports
Appetite loss after Lotilaner + Moxidectin + Praziquantel + Pyrantel (Credelio Quattro) 20 reports · 0.6% of its reports

All reported side effects of Sarolaner in dogs · Medicines most reported with appetite loss