Underdose after Prednisolone + Trimeprazine in dogs

The FDA has received 40 reports of underdose in dogs after Prednisolone + Trimeprazine. That is 1.9% of all reports for this medicine, compared with 1.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

40Reports

25%Marked serious

7.5%Recovered

2.5%Died or euthanised

9 daysTypical onset

How soon it started

Same day

8 32%

1–2 days

1 4.0%

3–7 days

3 12%

1–4 weeks

8 32%

Over a month

5 20%

How the animals did

Recovered

3 7.5%

Still unwell when reported

19 48%

Euthanised

1 2.5%

Not known

17 43%

Problems reported at the same time

Didn't work as expected

27 68%

Overdose

4 10%

Inappropriate schedule of drug administration

4 10%

Urinary tract infection

3 7.5%

3 7.5%

3 7.5%

3 7.5%

3 7.5%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Prednisolone reduces inflammation and immune activity.

Steroids commonly cause increased thirst, urination and appetite, especially at higher doses.

Questions owners ask

Can Prednisolone + Trimeprazine cause underdose in dogs?: 40 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 9 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Underdose with similar medicines

Underdose after Prednisone 163 reports · 1.8% of its reports
Underdose after Dexamethasone 28 reports · 1.0% of its reports

All reported side effects of Prednisolone + Trimeprazine in dogs · Medicines most reported with underdose