Eosinopenia after Oclacitinib (Apoquel) in dogs

109 reports to the FDA describe eosinopenia in dogs given Oclacitinib. That is 0.4% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

109Reports

51%Marked serious

9.2%Recovered

13%Died or euthanised

85 daysTypical onset

How soon it started

Same day

3 4.9%

1–2 days

6 9.8%

3–7 days

3 4.9%

1–4 weeks

10 16%

Over a month

39 64%

How the animals did

Recovered

10 9.2%

Still unwell when reported

61 56%

Died

3 2.8%

Euthanised

11 10%

Not known

24 22%

Problems reported at the same time

63 58%

56 51%

55 50%

45 41%

41 38%

33 30%

Decreased haematocrit

29 27%

Leukopenia

24 22%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Oclacitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Apoquel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Oclacitinib cause eosinopenia in dogs?: 109 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 85 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Eosinopenia with similar medicines

Eosinopenia after Cyclosporine (Atopica) 29 reports · 0.2% of its reports
Eosinopenia after Ilunocitinib (Zenrelia) 106 reports · 4.8% of its reports

All reported side effects of Oclacitinib in dogs · Medicines most reported with eosinopenia