Leukopenia after Oclacitinib (Apoquel) in dogs

81 reports to the FDA describe leukopenia in dogs given Oclacitinib. That is 0.3% of all reports for this medicine, compared with 0.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

81Reports

30%Marked serious

8.6%Recovered

7.4%Died or euthanised

131 daysTypical onset

How soon it started

Same day

2 4.2%

1–2 days

2 4.2%

3–7 days

0 0.0%

1–4 weeks

4 8.3%

Over a month

40 83%

How the animals did

Recovered

7 8.6%

Still unwell when reported

50 62%

Died

1 1.2%

Euthanised

5 6.2%

Not known

18 22%

Problems reported at the same time

Neutropenia

59 73%

Lymphopenia

26 32%

Eosinopenia

24 30%

Decreased haematocrit

21 26%

20 25%

14 17%

14 17%

12 15%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Oclacitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Apoquel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Oclacitinib cause leukopenia in dogs?: 81 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 131 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Leukopenia with similar medicines

Leukopenia after Ilunocitinib (Zenrelia) 133 reports · 6.1% of its reports

All reported side effects of Oclacitinib in dogs · Medicines most reported with leukopenia