Decreased packed cell volume (pcv) after Oclacitinib (Apoquel) in dogs

154 reports to the FDA describe decreased packed cell volume (pcv) in dogs given Oclacitinib. That is 0.5% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

154Reports
47%Marked serious
11%Recovered
16%Died or euthanised
56 daysTypical onset
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How soon it started

Same day
6 6.3%
1–2 days
6 6.3%
3–7 days
4 4.2%
1–4 weeks
17 18%
Over a month
62 65%

How the animals did

Recovered
16 10%
Recovered with lasting effects
1 0.6%
Still unwell when reported
109 71%
Died
6 3.9%
Euthanised
18 12%
Not known
4 2.6%

Problems reported at the same time

Age of the animals

Under 1 year
0
1–3 years
11
4–7 years
52
8–11 years
58
12+ years
31

About this medicine

Oclacitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Apoquel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Oclacitinib cause decreased packed cell volume (pcv) in dogs?
154 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 56 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Decreased packed cell volume (pcv) with similar medicines

All reported side effects of Oclacitinib in dogs · Medicines most reported with decreased packed cell volume (pcv)