Respiratory tract disorder after Moxidectin (ProHeart 6) in dogs

29 reports to the FDA describe respiratory tract disorder in dogs given Moxidectin. That is 0.1% of all reports for this medicine, compared with 0.1% across reports for all dog medicines.

29Reports
48%Marked serious
6.9%Recovered
45%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
8 47%
1–2 days
4 24%
3–7 days
0 0.0%
1–4 weeks
3 18%
Over a month
2 12%

How the animals did

Recovered
2 6.9%
Still unwell when reported
8 28%
Died
10 34%
Euthanised
3 10%
Not known
6 21%

Problems reported at the same time

Age of the animals

Under 1 year
4
1–3 years
7
4–7 years
9
8–11 years
8
12+ years
1

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this ingredient include ProHeart 6, ProHeart 12. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin cause respiratory tract disorder in dogs?
29 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Respiratory tract disorder with similar medicines

All reported side effects of Moxidectin in dogs · Medicines most reported with respiratory tract disorder