Respiratory sound after Moxidectin (ProHeart 6) in dogs

36 reports to the FDA describe respiratory sound in dogs given Moxidectin. That is 0.1% of all reports for this medicine, compared with 0.1% across reports for all dog medicines.

36Reports
31%Marked serious
11%Recovered
39%Died or euthanised
Same dayTypical onset
SponsoredWorried about your pet? Ask a veterinarian online, 24/7

How soon it started

Same day
7 54%
1–2 days
2 15%
3–7 days
1 7.7%
1–4 weeks
2 15%
Over a month
1 7.7%

How the animals did

Recovered
4 11%
Still unwell when reported
4 11%
Died
14 39%
Not known
14 39%

Problems reported at the same time

Age of the animals

Under 1 year
2
1–3 years
12
4–7 years
8
8–11 years
7
12+ years
5

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this ingredient include ProHeart 6, ProHeart 12. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin cause respiratory sound in dogs?
36 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Respiratory sound with similar medicines

All reported side effects of Moxidectin in dogs · Medicines most reported with respiratory sound