Reduced responses after Moxidectin (ProHeart 6) in dogs
55 reports to the FDA describe reduced responses in dogs given Moxidectin. That is 0.1% of all reports for this medicine, compared with 0.1% across reports for all dog medicines.
55Reports
73%Marked serious
35%Recovered
20%Died or euthanised
Same dayTypical onset
Sponsored
How soon it started
How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).
Products with this ingredient include ProHeart 6, ProHeart 12. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.
Questions owners ask
- Can Moxidectin cause reduced responses in dogs?
- 55 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- How soon after a dose was it reported?
- In half of the reports with dates, it started within the same day of the first dose.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Reduced responses with similar medicines
- Reduced responses after Ivermectin + Pyrantel (Heartgard Plus) 57 reports · 0.0% of its reports
- Reduced responses after Milbemycin Oxime + Spinosad (Trifexis) 233 reports · 0.2% of its reports
All reported side effects of Moxidectin in dogs · Medicines most reported with reduced responses