Lateral recumbency after Moxidectin (ProHeart 6) in dogs

358 reports to the FDA describe lateral recumbency in dogs given Moxidectin. That is 0.7% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

358Reports

93%Marked serious

33%Recovered

19%Died or euthanised

Same dayTypical onset

How soon it started

Same day

292 85%

1–2 days

25 7.3%

3–7 days

13 3.8%

1–4 weeks

5 1.5%

Over a month

8 2.3%

How the animals did

Recovered

119 33%

Still unwell when reported

164 46%

Died

38 11%

Euthanised

31 8.7%

Not known

6 1.7%

Problems reported at the same time

255 71%

234 65%

125 35%

102 28%

99 28%

98 27%

75 21%

69 19%

Age of the animals

Under 1 year

1–3 years

204

4–7 years

8–11 years

12+ years

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this ingredient include ProHeart 6, ProHeart 12. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin cause lateral recumbency in dogs?: 358 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Lateral recumbency with similar medicines

Lateral recumbency after Ivermectin + Pyrantel (Heartgard Plus) 186 reports · 0.1% of its reports
Lateral recumbency after Milbemycin Oxime + Spinosad (Trifexis) 178 reports · 0.1% of its reports
Lateral recumbency after Milbemycin Oxime + Praziquantel (Interceptor Plus) 33 reports · 0.1% of its reports
Lateral recumbency after Selamectin (Revolution) 21 reports · 0.1% of its reports
Lateral recumbency after Ivermectin (Heartgard) 46 reports · 0.4% of its reports

All reported side effects of Moxidectin in dogs · Medicines most reported with lateral recumbency