Lameness after Moxidectin (ProHeart 6) in dogs

363 reports to the FDA describe lameness in dogs given Moxidectin. That is 0.7% of all reports for this medicine, compared with 0.6% across reports for all dog medicines.

363Reports

41%Marked serious

9.9%Recovered

13%Died or euthanised

1 daysTypical onset

How soon it started

Same day

77 35%

1–2 days

56 26%

3–7 days

28 13%

1–4 weeks

26 12%

Over a month

32 15%

How the animals did

Recovered

36 9.9%

Still unwell when reported

158 44%

Died

25 6.9%

Euthanised

24 6.6%

Not known

120 33%

Problems reported at the same time

131 36%

120 33%

84 23%

64 18%

60 17%

50 14%

49 13%

Injection site reaction

41 11%

Age of the animals

Under 1 year

1–3 years

4–7 years

136

8–11 years

12+ years

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this ingredient include ProHeart 6, ProHeart 12. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin cause lameness in dogs?: 363 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Lameness with similar medicines

Lameness after Ivermectin + Pyrantel (Heartgard Plus) 319 reports · 0.2% of its reports
Lameness after Milbemycin Oxime + Spinosad (Trifexis) 452 reports · 0.3% of its reports
Lameness after Milbemycin Oxime + Praziquantel (Interceptor Plus) 233 reports · 0.7% of its reports
Lameness after Milbemycin Oxime (Interceptor) 115 reports · 0.4% of its reports
Lameness after Selamectin (Revolution) 100 reports · 0.3% of its reports
Lameness after Ivermectin (Heartgard) 59 reports · 0.5% of its reports

All reported side effects of Moxidectin in dogs · Medicines most reported with lameness