Hyperglycaemia after Milbemycin Oxime + Praziquantel (Interceptor Plus) in dogs

77 reports to the FDA describe hyperglycaemia in dogs given Milbemycin Oxime + Praziquantel. That is 0.2% of all reports for this medicine, compared with 0.5% across reports for all dog medicines, so it is reported less often than average with this medicine.

77Reports

69%Marked serious

14%Recovered

16%Died or euthanised

23 daysTypical onset

How soon it started

Same day

11 22%

1–2 days

5 10%

3–7 days

2 4.1%

1–4 weeks

7 14%

Over a month

24 49%

How the animals did

Recovered

10 13%

Recovered with lasting effects

1 1.3%

Still unwell when reported

31 40%

Died

6 7.8%

Euthanised

6 7.8%

Not known

23 30%

Problems reported at the same time

37 48%

31 40%

28 36%

27 35%

21 27%

16 21%

14 18%

14 18%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly). Praziquantel treats tapeworms.

Products with this combination include Interceptor Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Milbemycin Oxime + Praziquantel cause hyperglycaemia in dogs?: 77 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 23 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Hyperglycaemia with similar medicines

Hyperglycaemia after Ivermectin + Pyrantel (Heartgard Plus) 225 reports · 0.2% of its reports
Hyperglycaemia after Milbemycin Oxime + Spinosad (Trifexis) 356 reports · 0.3% of its reports
Hyperglycaemia after Moxidectin (ProHeart 6) 208 reports · 0.4% of its reports
Hyperglycaemia after Milbemycin Oxime (Interceptor) 51 reports · 0.2% of its reports
Hyperglycaemia after Selamectin (Revolution) 58 reports · 0.2% of its reports
Hyperglycaemia after Ivermectin (Heartgard) 77 reports · 0.6% of its reports
Hyperglycaemia after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 23 reports · 0.3% of its reports

All reported side effects of Milbemycin Oxime + Praziquantel in dogs · Medicines most reported with hyperglycaemia